Construction of Bordetella pertussis strains with enhanced production of genetically-inactivated Pertussis Toxin and Pertactin by unmarked allelic exchange

BACKGROUND: Acellular Pertussis vaccines against whooping cough caused by Bordetella pertussis present a much-improved safety profile compared to the original vaccine of killed whole cells. The principal antigen of acellular Pertussis vaccine, Pertussis Toxin (PT), must be chemically inactivated to...

Descripción completa

Detalles Bibliográficos
Autores principales: Buasri, Wasin, Impoolsup, Attawut, Boonchird, Chuenchit, Luengchaichawange, Anocha, Prompiboon, Pannipa, Petre, Jean, Panbangred, Watanalai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349578/
https://www.ncbi.nlm.nih.gov/pubmed/22524455
http://dx.doi.org/10.1186/1471-2180-12-61

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349578/
https://www.ncbi.nlm.nih.gov/pubmed/22524455
http://dx.doi.org/10.1186/1471-2180-12-61

Ejemplares similares