Perifosine as a Potential Novel Anti-Cancer Agent Inhibits EGFR/MET-AKT Axis in Malignant Pleural Mesothelioma

BACKGROUND: PI3K/AKT signalling pathway is aberrantly active and plays a critical role for cell cycle progression of human malignant pleural mesothelioma (MMe) cells. AKT is one of the important cellular targets of perifosine, a novel bio-available alkylphospholipid that has displayed significant an...

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Detalles Bibliográficos
Autores principales: Pinton, Giulia, Manente, Arcangela Gabriella, Angeli, Giovanni, Mutti, Luciano, Moro, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349630/
https://www.ncbi.nlm.nih.gov/pubmed/22590625
http://dx.doi.org/10.1371/journal.pone.0036856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349630/
https://www.ncbi.nlm.nih.gov/pubmed/22590625
http://dx.doi.org/10.1371/journal.pone.0036856

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