Phosphorylation of Nicastrin by SGK1 Leads to Its Degradation through Lysosomal and Proteasomal Pathways

The gamma-secretase complex is involved in the intramembranous proteolysis of a variety of substrates, including the amyloid precursor protein and the Notch receptor. Nicastrin (NCT) is an essential component of the gamma-secretase complex and functions as a receptor for gamma-secretase substrates....

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Detalles Bibliográficos
Autores principales: Mo, Jung-Soon, Yoon, Ji-Hye, Hong, Ji-Ae, Kim, Mi-Yeon, Ann, Eun-Jung, Ahn, Ji-Seon, Kim, Su-Man, Baek, Hyeong-Jin, Lang, Florian, Choi, Eui-Ju, Park, Hee-Sae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349648/
https://www.ncbi.nlm.nih.gov/pubmed/22590650
http://dx.doi.org/10.1371/journal.pone.0037111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349648/
https://www.ncbi.nlm.nih.gov/pubmed/22590650
http://dx.doi.org/10.1371/journal.pone.0037111

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