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Distinct RGK GTPases Differentially Use α(1)- and Auxiliary β-Binding-Dependent Mechanisms to Inhibit Ca(V)1.2/Ca(V)2.2 Channels

Ca(V)1/Ca(V)2 channels, comprised of pore-forming α(1) and auxiliary (β,α(2)δ) subunits, control diverse biological responses in excitable cells. Molecules blocking Ca(V)1/Ca(V)2 channel currents (I (Ca)) profoundly regulate physiology and have many therapeutic applications. Rad/Rem/Rem2/Gem GTPases...

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Detalles Bibliográficos
Autores principales:	Yang, Tingting, Puckerin, Akil, Colecraft, Henry M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349659/ https://www.ncbi.nlm.nih.gov/pubmed/22590648 http://dx.doi.org/10.1371/journal.pone.0037079

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