Prostaglandin I(2) Signaling Drives Th17 Differentiation and Exacerbates Experimental Autoimmune Encephalomyelitis

BACKGROUND: Prostaglandin I(2) (PGI(2)), a lipid mediator currently used in treatment of human disease, is a critical regulator of adaptive immune responses. Although PGI(2) signaling suppressed Th1 and Th2 immune responses, the role of PGI(2) in Th17 differentiation is not known. METHODOLOGY/PRINCI...

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Detalles Bibliográficos
Autores principales: Zhou, Weisong, Dowell, Dustin R., Huckabee, Matthew M., Newcomb, Dawn C., Boswell, Madison G., Goleniewska, Kasia, Lotz, Matthew T., Toki, Shinji, Yin, Huiyong, Yao, Songyi, Natarajan, Chandramohan, Wu, Pingsheng, Sriram, Subramaniam, Breyer, Richard M., FitzGerald, Garret A., Peebles, R. Stokes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349674/
https://www.ncbi.nlm.nih.gov/pubmed/22590492
http://dx.doi.org/10.1371/journal.pone.0033518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349674/
https://www.ncbi.nlm.nih.gov/pubmed/22590492
http://dx.doi.org/10.1371/journal.pone.0033518

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