Cargando…

An in vivo cis-Regulatory Screen at the Type 2 Diabetes Associated TCF7L2 Locus Identifies Multiple Tissue-Specific Enhancers

Genome-wide association studies (GWAS) have repeatedly shown an association between non-coding variants in the TCF7L2 locus and risk for type 2 diabetes (T2D), implicating a role for cis-regulatory variation within this locus in disease etiology. Supporting this hypothesis, we previously localized c...

Descripción completa

Detalles Bibliográficos
Autores principales: Savic, Daniel, Bell, Graeme I., Nobrega, Marcelo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349716/
https://www.ncbi.nlm.nih.gov/pubmed/22590553
http://dx.doi.org/10.1371/journal.pone.0036501