In silico identification of novel lead compounds with AT(1 )receptor antagonist activity: successful application of chemical database screening protocol

BACKGROUND: AT(1 )receptor antagonists are clinically effective drugs for the treatment of hypertension, cardiovascular, and related disorders. In an attempt to identify new AT(1 )receptor antagonists, a pharmacophore-based virtual screening protocol was applied. The pharmacophore models were genera...

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Detalles Bibliográficos
Autores principales: Pal, Mahima, Paliwal, Sarvesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2012
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349973/
https://www.ncbi.nlm.nih.gov/pubmed/22380004
http://dx.doi.org/10.1186/2191-2858-2-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349973/
https://www.ncbi.nlm.nih.gov/pubmed/22380004
http://dx.doi.org/10.1186/2191-2858-2-7

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