Suppression of the Nrf2-Dependent Antioxidant Response by Glucocorticoids and 11β-HSD1-Mediated Glucocorticoid Activation in Hepatic Cells

BACKGROUND: Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor regulating a plethora of detoxifying enzymes and antioxidant genes involved in drug metabolism and defence against oxidative stress. The glucocorticoid receptor (GR) is a ligand-induced transcription factor...

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Detalles Bibliográficos
Autores principales: Kratschmar, Denise V., Calabrese, Diego, Walsh, Jo, Lister, Adam, Birk, Julia, Appenzeller-Herzog, Christian, Moulin, Pierre, Goldring, Chris E., Odermatt, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350474/
https://www.ncbi.nlm.nih.gov/pubmed/22606287
http://dx.doi.org/10.1371/journal.pone.0036774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350474/
https://www.ncbi.nlm.nih.gov/pubmed/22606287
http://dx.doi.org/10.1371/journal.pone.0036774

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