Induction of Cellular Senescence by Doxorubicin Is Associated with Upregulated miR-375 and Induction of Autophagy in K562 Cells

BACKGROUND: Cellular senescence is a specialized form of growth arrest that is generally irreversible. Upregulated p16, p53, and p21 expression and silencing of E2F target genes have been characterized to promote the establishment of senescence. It can be further aided by the transcriptional repress...

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Detalles Bibliográficos
Autores principales: Yang, Ming-Yu, Lin, Pai-Mei, Liu, Yi-Chang, Hsiao, Hui-Hua, Yang, Wen-Chi, Hsu, Jui-Feng, Hsu, Cheng-Ming, Lin, Sheng-Fung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350486/
https://www.ncbi.nlm.nih.gov/pubmed/22606351
http://dx.doi.org/10.1371/journal.pone.0037205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350486/
https://www.ncbi.nlm.nih.gov/pubmed/22606351
http://dx.doi.org/10.1371/journal.pone.0037205

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