Haploinsufficiency of the E3 Ubiquitin Ligase C-Terminus of Heat Shock Cognate 70 Interacting Protein (CHIP) Produces Specific Behavioral Impairments

The multifunctional E3 ubiquitin ligase CHIP is an essential interacting partner of HSP70, which together promote the proteasomal degradation of client proteins. Acute CHIP overexpression provides neuroprotection against neurotoxic mitochondrial stress, glucocorticoids, and accumulation of toxic amy...

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Detalles Bibliográficos
Autores principales: McLaughlin, BethAnn, Buendia, Matthew A., Saborido, Tommy P., Palubinsky, Amy M., Stankowski, Jeannette N., Stanwood, Gregg D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350526/
https://www.ncbi.nlm.nih.gov/pubmed/22606257
http://dx.doi.org/10.1371/journal.pone.0036340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350526/
https://www.ncbi.nlm.nih.gov/pubmed/22606257
http://dx.doi.org/10.1371/journal.pone.0036340

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