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Haploinsufficiency of the E3 Ubiquitin Ligase C-Terminus of Heat Shock Cognate 70 Interacting Protein (CHIP) Produces Specific Behavioral Impairments
The multifunctional E3 ubiquitin ligase CHIP is an essential interacting partner of HSP70, which together promote the proteasomal degradation of client proteins. Acute CHIP overexpression provides neuroprotection against neurotoxic mitochondrial stress, glucocorticoids, and accumulation of toxic amy...
Autores principales: | McLaughlin, BethAnn, Buendia, Matthew A., Saborido, Tommy P., Palubinsky, Amy M., Stankowski, Jeannette N., Stanwood, Gregg D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350526/ https://www.ncbi.nlm.nih.gov/pubmed/22606257 http://dx.doi.org/10.1371/journal.pone.0036340 |
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