c-Jun N-terminal kinase–mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks

The E3 ubiquitin ligase Rad18 chaperones DNA polymerase η (Polη) to sites of UV-induced DNA damage and monoubiquitinates proliferating cell nuclear antigen (PCNA), facilitating engagement of Polη with stalled replication forks and promoting translesion synthesis (TLS). It is unclear how Rad18 activi...

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Detalles Bibliográficos
Autores principales: Barkley, Laura R., Palle, Komaraiah, Durando, Michael, Day, Tovah A., Gurkar, Aditi, Kakusho, Naoko, Li, Jianying, Masai, Hisao, Vaziri, Cyrus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350557/
https://www.ncbi.nlm.nih.gov/pubmed/22456510
http://dx.doi.org/10.1091/mbc.E11-10-0829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350557/
https://www.ncbi.nlm.nih.gov/pubmed/22456510
http://dx.doi.org/10.1091/mbc.E11-10-0829

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