Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

It is well established that autism spectrum disorders (ASD) have a strong genetic component. However, for at least 70% of cases, the underlying genetic cause is unknown(1). Under the hypothesis that de novo mutations underlie a substantial fraction of the risk for developing ASD in families with no...

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Detalles Bibliográficos
Autores principales: O’Roak, Brian J., Vives, Laura, Girirajan, Santhosh, Karakoc, Emre, Krumm, Nik, Coe, Bradley P., Levy, Roie, Ko, Arthur, Lee, Choli, Smith, Joshua D., Turner, Emily H., Stanaway, Ian B., Vernot, Benjamin, Malig, Maika, Baker, Carl, Reilly, Beau, Akey, Joshua M., Borenstein, Elhanan, Rieder, Mark J., Nickerson, Deborah A., Bernier, Raphael, Shendure, Jay, Eichler, Evan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350576/
https://www.ncbi.nlm.nih.gov/pubmed/22495309
http://dx.doi.org/10.1038/nature10989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350576/
https://www.ncbi.nlm.nih.gov/pubmed/22495309
http://dx.doi.org/10.1038/nature10989

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