A Long ncRNA Links Copy Number Variation to a Polycomb/Trithorax Epigenetic Switch in FSHD Muscular Dystrophy

Repetitive sequences account for more than 50% of the human genome. Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal-dominant disease associated with reduction in the copy number of the D4Z4 repeat mapping to 4q35. By an unknown mechanism, D4Z4 deletion causes an epigenetic switch leadi...

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Detalles Bibliográficos
Autores principales: Cabianca, Daphne S., Casa, Valentina, Bodega, Beatrice, Xynos, Alexandros, Ginelli, Enrico, Tanaka, Yujiro, Gabellini, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350859/
https://www.ncbi.nlm.nih.gov/pubmed/22541069
http://dx.doi.org/10.1016/j.cell.2012.03.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350859/
https://www.ncbi.nlm.nih.gov/pubmed/22541069
http://dx.doi.org/10.1016/j.cell.2012.03.035

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