Altered p16(INK4) and RB1 Expressions Are Associated with Poor Prognosis in Patients with Nonsmall Cell Lung Cancer

p16(INK4) and RB1 are two potent cell cycle regulators to control the G1/S transition by interacting with CDK4/6, E2F, and D-type cyclins, respectively. Depending on the tumour type, genetic alterations resulting in the functional inactivation have frequently been reported in both genes. By contrast...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Weiqiang, Huang, Cheng C., Otterson, Gregory A., Leon, Marino E., Tang, Yan, Shilo, Konstantin, Villalona, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350860/
https://www.ncbi.nlm.nih.gov/pubmed/22619677
http://dx.doi.org/10.1155/2012/957437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350860/
https://www.ncbi.nlm.nih.gov/pubmed/22619677
http://dx.doi.org/10.1155/2012/957437

Ejemplares similares