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Cleavage of ST6Gal I by Radiation-Induced BACE1 Inhibits Golgi-Anchored ST6Gal I-Mediated Sialylation of Integrin β1 and Migration in Colon Cancer Cells

BACKGROUND: Previously, we found that β-galactoside α2,6-sialyltransferase (ST6Gal I), an enzyme that adds sialic acids to N-linked oligosaccharides of glycoproteins and is frequently overexpressed in cancer cells, is up-regulated by ionizing radiation (IR) and cleaved to a form possessing catalytic...

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Detalles Bibliográficos
Autores principales: Lee, Minyoung, Park, Jung-Jin, Ko, Young-Gyu, Lee, Yun-Sil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351029/
https://www.ncbi.nlm.nih.gov/pubmed/22449099
http://dx.doi.org/10.1186/1748-717X-7-47