Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain

MDC1 is a key mediator of the DNA-damage response in mammals with several phosphorylation-dependent protein interaction domains. The function of its N-terminal forkhead-associated (FHA) domain remains elusive. Here, we show with structural, biochemical and cellular data that the FHA domain mediates...

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Detalles Bibliográficos
Autores principales: Liu, Jinping, Luo, Shukun, Zhao, Hongchang, Liao, Ji, Li, Jing, Yang, Chunying, Xu, Bo, Stern, David F., Xu, Xingzhi, Ye, Keqiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351156/
https://www.ncbi.nlm.nih.gov/pubmed/22234877
http://dx.doi.org/10.1093/nar/gkr1296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351156/
https://www.ncbi.nlm.nih.gov/pubmed/22234877
http://dx.doi.org/10.1093/nar/gkr1296

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