The porphyrin TmPyP4 unfolds the extremely stable G-quadruplex in MT3-MMP mRNA and alleviates its repressive effect to enhance translation in eukaryotic cells

We report that the cationic porphyrin TmPyP4, which is known mainly as a DNA G-quadruplex stabilizer, unfolds an unusually stable all purine RNA G-quadruplex (M3Q) that is located in the 5′-UTR of MT3-MMP mRNA. When the interaction between TmPyP4 and M3Q was monitored by UV spectroscopy a 22-nm bath...

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Detalles Bibliográficos
Autores principales: Morris, Mark J., Wingate, Katherine L., Silwal, Jagannath, Leeper, Thomas C., Basu, Soumitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351169/
https://www.ncbi.nlm.nih.gov/pubmed/22266651
http://dx.doi.org/10.1093/nar/gkr1308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351169/
https://www.ncbi.nlm.nih.gov/pubmed/22266651
http://dx.doi.org/10.1093/nar/gkr1308

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