Cargando…
Plasticity of Adult Human Pancreatic Duct Cells by Neurogenin3-Mediated Reprogramming
AIMS/HYPOTHESIS: Duct cells isolated from adult human pancreas can be reprogrammed to express islet beta cell genes by adenoviral transduction of the developmental transcription factor neurogenin3 (Ngn3). In this study we aimed to fully characterize the extent of this reprogramming and intended to i...
Autores principales: | Swales, Nathalie, Martens, Geert A., Bonné, Stefan, Heremans, Yves, Borup, Rehannah, Van de Casteele, Mark, Ling, Zhidong, Pipeleers, Daniel, Ravassard, Philippe, Nielsen, Finn, Ferrer, Jorge, Heimberg, Harry |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351393/ https://www.ncbi.nlm.nih.gov/pubmed/22606327 http://dx.doi.org/10.1371/journal.pone.0037055 |
Ejemplares similares
-
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3
por: Heremans, Yves, et al.
Publicado: (2002) -
Ectopic Expression of E2F1 Stimulates β-Cell Proliferation and Function
por: Grouwels, Gael, et al.
Publicado: (2010) -
Conditional Hypovascularization and Hypoxia in Islets Do Not Overtly Influence Adult β-Cell Mass or Function
por: D'Hoker, Joke, et al.
Publicado: (2013) -
Neurogenin 3(+) cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas
por: Van de Casteele, M, et al.
Publicado: (2013) -
Clusters of Conserved Beta Cell Marker Genes for Assessment of Beta Cell Phenotype
por: Martens, Geert A., et al.
Publicado: (2011)