Urate and Its Transgenic Depletion Modulate Neuronal Vulnerability in a Cellular Model of Parkinson's Disease

Urate is a major antioxidant as well as the enzymatic end product of purine metabolism in humans. Higher levels correlate with a reduced risk of developing Parkinson's disease (PD) and with a slower rate of PD progression. In this study we investigated the effects of modulating intracellular ur...

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Detalles Bibliográficos
Autores principales: Cipriani, Sara, Desjardins, Cody A., Burdett, Thomas C., Xu, Yuehang, Xu, Kui, Schwarzschild, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351394/
https://www.ncbi.nlm.nih.gov/pubmed/22606360
http://dx.doi.org/10.1371/journal.pone.0037331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351394/
https://www.ncbi.nlm.nih.gov/pubmed/22606360
http://dx.doi.org/10.1371/journal.pone.0037331

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