Suppression of Ribosomal Function Triggers Innate Immune Signaling through Activation of the NLRP3 Inflammasome

Some inflammatory stimuli trigger activation of the NLRP3 inflammasome by inducing efflux of cellular potassium. Loss of cellular potassium is known to potently suppress protein synthesis, leading us to test whether the inhibition of protein synthesis itself serves as an activating signal for the NL...

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Detalles Bibliográficos
Autores principales: Vyleta, Meghan L., Wong, John, Magun, Bruce E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351443/
https://www.ncbi.nlm.nih.gov/pubmed/22606244
http://dx.doi.org/10.1371/journal.pone.0036044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351443/
https://www.ncbi.nlm.nih.gov/pubmed/22606244
http://dx.doi.org/10.1371/journal.pone.0036044

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