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Molecular Evolution of a Peptide GPCR Ligand Driven by Artificial Neural Networks
Peptide ligands of G protein-coupled receptors constitute valuable natural lead structures for the development of highly selective drugs and high-affinity tools to probe ligand-receptor interaction. Currently, pharmacological and metabolic modification of natural peptides involves either an iterativ...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351444/ https://www.ncbi.nlm.nih.gov/pubmed/22606313 http://dx.doi.org/10.1371/journal.pone.0036948 |