Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrest

Anti-mitotic chemotherapeutic agents such as taxanes activate the spindle assembly checkpoint (SAC) to arrest anaphase onset, but taxane-exposed cells eventually undergo slippage to exit mitosis. The therapeutic efficacy of taxanes depends on whether slippage after SAC arrest culminates in continued...

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Detalles Bibliográficos
Autores principales: Russell, P, Hennessy, B T, Li, J, Carey, M S, Bast, R C, Freeman, T, Venkitaraman, A R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351588/
https://www.ncbi.nlm.nih.gov/pubmed/22056875
http://dx.doi.org/10.1038/onc.2011.431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351588/
https://www.ncbi.nlm.nih.gov/pubmed/22056875
http://dx.doi.org/10.1038/onc.2011.431

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