Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)

[Image: see text] Following a program undertaken to identify hit compounds against NADH:ubiquinone oxidoreductase (PfNDH2), a novel enzyme target within the malaria parasite Plasmodium falciparum, hit to lead optimization led to identification of CK-2-68, a molecule suitable for further development....

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Detalles Bibliográficos
Autores principales: Leung, Suet C., Gibbons, Peter, Amewu, Richard, Nixon, Gemma L., Pidathala, Chandrakala, Hong, W. David, Pacorel, Bénédicte, Berry, Neil G., Sharma, Raman, Stocks, Paul A., Srivastava, Abhishek, Shone, Alison E., Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Hill, Alasdair, Fisher, Nicholas E., Warman, Ashley J., Biagini, Giancarlo A., Ward, Stephen A., O’Neill, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351724/
https://www.ncbi.nlm.nih.gov/pubmed/22364417
http://dx.doi.org/10.1021/jm201184h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351724/
https://www.ncbi.nlm.nih.gov/pubmed/22364417
http://dx.doi.org/10.1021/jm201184h

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