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The expression of spinal methyl-CpG-binding protein 2, DNA methyltransferases and histone deacetylases is modulated in persistent pain states
BACKGROUND: DNA CpG methylation is carried out by DNA methyltransferases and induces chromatin remodeling and gene silencing through a transcription repressor complex comprising the methyl-CpG-binding protein 2 (MeCP2) and a subset of histone deacetylases. Recently, we have found that MeCP2 activity...
Autores principales: | Tochiki, Keri K, Cunningham, Joel, Hunt, Stephen P, Géranton, Sandrine M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351747/ https://www.ncbi.nlm.nih.gov/pubmed/22369085 http://dx.doi.org/10.1186/1744-8069-8-14 |
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