Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

BACKGROUND: Glutathione (GSH) plays an important role in neuronal oxidant defence. Depletion of cellular GSH is observed in neurodegenerative diseases and thereby contributes to the associated oxidative stress and Ca(2+ )dysregulation. Whether depletion of cellular GSH, associated with neuronal sene...

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Detalles Bibliográficos
Autores principales: Belrose, Jillian C, Xie, Yu-Feng, Gierszewski, Lynn J, MacDonald, John F, Jackson, Michael F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352021/
https://www.ncbi.nlm.nih.gov/pubmed/22487454
http://dx.doi.org/10.1186/1756-6606-5-11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352021/
https://www.ncbi.nlm.nih.gov/pubmed/22487454
http://dx.doi.org/10.1186/1756-6606-5-11

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