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Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

BACKGROUND: Glutathione (GSH) plays an important role in neuronal oxidant defence. Depletion of cellular GSH is observed in neurodegenerative diseases and thereby contributes to the associated oxidative stress and Ca(2+ )dysregulation. Whether depletion of cellular GSH, associated with neuronal sene...

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Detalles Bibliográficos
Autores principales:	Belrose, Jillian C, Xie, Yu-Feng, Gierszewski, Lynn J, MacDonald, John F, Jackson, Michael F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352021/ https://www.ncbi.nlm.nih.gov/pubmed/22487454 http://dx.doi.org/10.1186/1756-6606-5-11

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