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Clues to γ-secretase, huntingtin and Hirano body normal function using the model organism Dictyostelium discoideum
Many neurodegenerative disorders, although related by their destruction of brain function, display remarkable cellular and/or regional pathogenic specificity likely due to a deregulated functionality of the mutant protein. However, neurodegenerative disease genes, for example huntingtin (HTT), the a...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352040/ https://www.ncbi.nlm.nih.gov/pubmed/22489754 http://dx.doi.org/10.1186/1423-0127-19-41 |