Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme

The transketolase (TKT) enzyme in Mycobacterium tuberculosis represents a novel drug target for tuberculosis treatment and has low homology with the orthologous human enzyme. Here, we report on the structural and kinetic characterization of the transketolase from M. tuberculosis (TBTKT), a homodimer...

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Detalles Bibliográficos
Autores principales: Fullam, Elizabeth, Pojer, Florence, Bergfors, Terese, Jones, T. Alwyn, Cole, Stewart T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352088/
https://www.ncbi.nlm.nih.gov/pubmed/22645655
http://dx.doi.org/10.1098/rsob.110026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352088/
https://www.ncbi.nlm.nih.gov/pubmed/22645655
http://dx.doi.org/10.1098/rsob.110026

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