The distribution of a germline methylation marker suggests a regional mechanism of LINE-1 silencing by the piRNA-PIWI system

BACKGROUND: A defense system against transposon activity in the human germline based on PIWI proteins and piRNA has recently been discovered. It represses the activity of LINE-1 elements via DNA methylation by a largely unknown mechanism. Based on the dispersed distribution of clusters of piRNA gene...

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Detalles Bibliográficos
Autores principales: Sigurdsson, Martin I, Smith, Albert V, Bjornsson, Hans T, Jonsson, Jon J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352111/
https://www.ncbi.nlm.nih.gov/pubmed/22530917
http://dx.doi.org/10.1186/1471-2156-13-31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352111/
https://www.ncbi.nlm.nih.gov/pubmed/22530917
http://dx.doi.org/10.1186/1471-2156-13-31

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