Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology

BACKGROUND: A growing body of evidence indicates that inflammation is one of the earliest neuropathological events in Alzheimer's disease. Accordingly, we have recently shown the occurrence of an early, pro-inflammatory reaction in the hippocampus of young, three-month-old transgenic McGill-Thy...

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Detalles Bibliográficos
Autores principales: Ferretti, Maria Teresa, Allard, Simon, Partridge, Vanessa, Ducatenzeiler, Adriana, Cuello, A Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352127/
https://www.ncbi.nlm.nih.gov/pubmed/22472085
http://dx.doi.org/10.1186/1742-2094-9-62

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352127/
https://www.ncbi.nlm.nih.gov/pubmed/22472085
http://dx.doi.org/10.1186/1742-2094-9-62

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