Therapy for nifedipine-induced gingival overgrowth by saireito in rats

OBJECTIVE: A calcium antagonist, nifedipine, causes gingival overgrowth as a side effect. It has been confirmed that the Japanese traditional medicine, Saireito, inhibits the nifedipine-induced proliferation of gingival fibroblasts in vitro. We performed an in vivo experiment to determine whether Sa...

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Autores principales: Hattori, T, Nakano, K, Kawakami, T, Tamura, A, Ara, T, Wang, PL
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352291/
https://www.ncbi.nlm.nih.gov/pubmed/19948446
http://dx.doi.org/10.1186/2047-783X-14-11-497
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author Hattori, T
Nakano, K
Kawakami, T
Tamura, A
Ara, T
Wang, PL
author_facet Hattori, T
Nakano, K
Kawakami, T
Tamura, A
Ara, T
Wang, PL
author_sort Hattori, T
collection PubMed
description OBJECTIVE: A calcium antagonist, nifedipine, causes gingival overgrowth as a side effect. It has been confirmed that the Japanese traditional medicine, Saireito, inhibits the nifedipine-induced proliferation of gingival fibroblasts in vitro. We performed an in vivo experiment to determine whether Saireito has a therapeutic use in the treatment of nifedipine-induced gingival overgrowth. METHODS: The rats had significant gingival overgrowth induced by the administration of nifedipine. The space between the submandibular incisors and the width of buccal gingiva of maxillary left first molar were macroscopically measured. The buccal gingiva was microscopically examined. RESULTS: Eight weeks after Saireito was administrated together with nifedipine, Saireito decreased both the incisor space and the gingiva width which had been enlarged by nifedipine and furthermore, the area of connective tissue of nifedipine + Saireito group was significantly smaller than that of nifedipine alone. CONCLUSION: In conclusion, Saireito may be clinically effective in therapy for calcium antagonist-induced gingival overgrowth.
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spelling pubmed-33522912012-05-16 Therapy for nifedipine-induced gingival overgrowth by saireito in rats Hattori, T Nakano, K Kawakami, T Tamura, A Ara, T Wang, PL Eur J Med Res Research OBJECTIVE: A calcium antagonist, nifedipine, causes gingival overgrowth as a side effect. It has been confirmed that the Japanese traditional medicine, Saireito, inhibits the nifedipine-induced proliferation of gingival fibroblasts in vitro. We performed an in vivo experiment to determine whether Saireito has a therapeutic use in the treatment of nifedipine-induced gingival overgrowth. METHODS: The rats had significant gingival overgrowth induced by the administration of nifedipine. The space between the submandibular incisors and the width of buccal gingiva of maxillary left first molar were macroscopically measured. The buccal gingiva was microscopically examined. RESULTS: Eight weeks after Saireito was administrated together with nifedipine, Saireito decreased both the incisor space and the gingiva width which had been enlarged by nifedipine and furthermore, the area of connective tissue of nifedipine + Saireito group was significantly smaller than that of nifedipine alone. CONCLUSION: In conclusion, Saireito may be clinically effective in therapy for calcium antagonist-induced gingival overgrowth. BioMed Central 2009-11-03 /pmc/articles/PMC3352291/ /pubmed/19948446 http://dx.doi.org/10.1186/2047-783X-14-11-497 Text en Copyright ©2009 I. Holzapfel Publishers
spellingShingle Research
Hattori, T
Nakano, K
Kawakami, T
Tamura, A
Ara, T
Wang, PL
Therapy for nifedipine-induced gingival overgrowth by saireito in rats
title Therapy for nifedipine-induced gingival overgrowth by saireito in rats
title_full Therapy for nifedipine-induced gingival overgrowth by saireito in rats
title_fullStr Therapy for nifedipine-induced gingival overgrowth by saireito in rats
title_full_unstemmed Therapy for nifedipine-induced gingival overgrowth by saireito in rats
title_short Therapy for nifedipine-induced gingival overgrowth by saireito in rats
title_sort therapy for nifedipine-induced gingival overgrowth by saireito in rats
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352291/
https://www.ncbi.nlm.nih.gov/pubmed/19948446
http://dx.doi.org/10.1186/2047-783X-14-11-497
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