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Mechanisms and Evolutionary Patterns of Mammalian and Avian Dosage Compensation
As a result of sex chromosome differentiation from ancestral autosomes, male mammalian cells only contain one X chromosome. It has long been hypothesized that X-linked gene expression levels have become doubled in males to restore the original transcriptional output, and that the resulting X overexp...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352821/ https://www.ncbi.nlm.nih.gov/pubmed/22615540 http://dx.doi.org/10.1371/journal.pbio.1001328 |