The Therapeutic effect of Memantine through the Stimulation of Synapse Formation and Dendritic Spine Maturation in Autism and Fragile X Syndrome

Although the pathogenic mechanisms that underlie autism are not well understood, there is evidence showing that metabotropic and ionotropic glutamate receptors are hyper-stimulated and the GABAergic system is hypo-stimulated in autism. Memantine is an uncompetitive antagonist of NMDA receptors and i...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Hongen, Dobkin, Carl, Sheikh, Ashfaq M., Malik, Mazhar, Brown, W. Ted, Li, Xiaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352866/
https://www.ncbi.nlm.nih.gov/pubmed/22615862
http://dx.doi.org/10.1371/journal.pone.0036981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352866/
https://www.ncbi.nlm.nih.gov/pubmed/22615862
http://dx.doi.org/10.1371/journal.pone.0036981

Ejemplares similares