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The Therapeutic effect of Memantine through the Stimulation of Synapse Formation and Dendritic Spine Maturation in Autism and Fragile X Syndrome

Although the pathogenic mechanisms that underlie autism are not well understood, there is evidence showing that metabotropic and ionotropic glutamate receptors are hyper-stimulated and the GABAergic system is hypo-stimulated in autism. Memantine is an uncompetitive antagonist of NMDA receptors and i...

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Detalles Bibliográficos
Autores principales:	Wei, Hongen, Dobkin, Carl, Sheikh, Ashfaq M., Malik, Mazhar, Brown, W. Ted, Li, Xiaohong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352866/ https://www.ncbi.nlm.nih.gov/pubmed/22615862 http://dx.doi.org/10.1371/journal.pone.0036981

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