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The Therapeutic effect of Memantine through the Stimulation of Synapse Formation and Dendritic Spine Maturation in Autism and Fragile X Syndrome
Although the pathogenic mechanisms that underlie autism are not well understood, there is evidence showing that metabotropic and ionotropic glutamate receptors are hyper-stimulated and the GABAergic system is hypo-stimulated in autism. Memantine is an uncompetitive antagonist of NMDA receptors and i...
Autores principales: | Wei, Hongen, Dobkin, Carl, Sheikh, Ashfaq M., Malik, Mazhar, Brown, W. Ted, Li, Xiaohong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352866/ https://www.ncbi.nlm.nih.gov/pubmed/22615862 http://dx.doi.org/10.1371/journal.pone.0036981 |
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