Cargando…

Functional Analysis of Conserved Motifs in Influenza Virus PB1 Protein

The influenza virus RNA polymerase complex is a heterotrimer composed of the PB1, PB2, and PA subunits. PB1, the catalytic core and structural backbone of the polymerase, possesses four highly conserved amino acid motifs that are present among all viral RNA-dependent RNA polymerases. A previous stud...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chu, Caroline, Fan, Shufang, Li, Chengjun, Macken, Catherine, Kim, Jin Hyun, Hatta, Masato, Neumann, Gabriele, Kawaoka, Yoshihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352917/ https://www.ncbi.nlm.nih.gov/pubmed/22615752 http://dx.doi.org/10.1371/journal.pone.0036113

Ejemplares similares

Egyptian H5N1 Influenza Viruses—Cause for Concern?
por: Neumann, Gabriele, et al.
Publicado: (2012)

Influenza Viruses Suitable for Studies in Syrian Hamsters
por: Fan, Shufang, et al.
Publicado: (2022)

Plasticity of the Influenza Virus H5 HA Protein
por: Kong, Huihui, et al.
Publicado: (2021)

Seasonality of influenza and other respiratory viruses
por: Neumann, Gabriele, et al.
Publicado: (2022)

Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A(H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus
por: Hatta, Masato, et al.
Publicado: (2018)

Development of high-yield influenza A virus vaccine viruses
por: Ping, Jihui, et al.
Publicado: (2015)

H3N2 Influenza Viruses with 12- or 16-Amino Acid Deletions in the Receptor-Binding Region of Their Hemagglutinin Protein
por: Kong, Huihui, et al.
Publicado: (2021)

Identification of mammalian-adapting mutations in the polymerase complex of an avian H5N1 influenza virus
por: Taft, Andrew S., et al.
Publicado: (2015)

Characterization of a Feline Influenza A(H7N2) Virus
por: Hatta, Masato, et al.
Publicado: (2018)

Amino acid changes in PB2 and HA affect the growth of a recombinant influenza virus expressing a fluorescent reporter protein
por: Katsura, Hiroaki, et al.
Publicado: (2016)

Quadrivalent Formulation of Intranasal Influenza Vaccine M2SR (M2-Deficient Single Replication) Protects against Drifted Influenza A and B Virus Challenge
por: Hill-Batorski, Lindsay, et al.
Publicado: (2023)

Growth of H5N1 Influenza A Viruses in the Upper Respiratory Tracts of Mice
por: Hatta, Masato, et al.
Publicado: (2007)

Quo Vadis Influenza?
por: Neumann, Gabriele, et al.
Publicado: (2021)

Predicting the Next Influenza Pandemics
por: Neumann, Gabriele, et al.
Publicado: (2019)

The first influenza pandemic of the new millennium
por: Neumann, Gabriele, et al.
Publicado: (2011)

Development of an Enhanced High-Yield Influenza Vaccine Backbone in Embryonated Chicken Eggs
por: Guan, Lizheng, et al.
Publicado: (2023)

Isolation of Highly Pathogenic H5N1 Influenza Viruses in 2009–2013 in Vietnam
por: Zhong, Gongxun, et al.
Publicado: (2019)

SARS-CoV-2 Interference of Influenza Virus Replication in Syrian Hamsters
por: Halfmann, Peter J, et al.
Publicado: (2021)

Host Range Restriction and Pathogenicity in the Context of Influenza Pandemic
por: Neumann, Gabriele, et al.
Publicado: (2006)

Longevity and Mechanism of Heterosubtypic Protection Induced by M2SR (M2-Deficient Single-Replication) Live Influenza Virus Vaccine in Mice
por: Sarawar, Sally, et al.
Publicado: (2022)

Amino acids substitutions in the PB2 protein of H7N9 influenza A viruses are important for virulence in mammalian hosts
por: Yamayoshi, Seiya, et al.
Publicado: (2015)

Which Virus Will Cause the Next Pandemic?
por: Neumann, Gabriele, et al.
Publicado: (2023)

Selection on hemagglutinin imposes a bottleneck during mammalian transmission of reassortant H5N1 influenza viruses
por: Wilker, Peter R., et al.
Publicado: (2013)

Experimental adaptation of an influenza H5 haemagglutinin (HA) confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets
por: Imai, Masaki, et al.
Publicado: (2012)

The Cellular DExD/H-Box RNA Helicase UAP56 Co-localizes With the Influenza A Virus NS1 Protein
por: Chiba, Shiho, et al.
Publicado: (2018)

Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems
por: McDermott, Jason E, et al.
Publicado: (2011)

Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus
por: Yamada, Shinya, et al.
Publicado: (2010)

Viral Replication Rate Regulates Clinical Outcome and CD8 T Cell Responses during Highly Pathogenic H5N1 Influenza Virus Infection in Mice
por: Hatta, Yasuko, et al.
Publicado: (2010)

Characterization of H9N2 Avian Influenza Viruses Isolated from Poultry Products in a Mouse Model
por: Murakami, Jurika, et al.
Publicado: (2022)

Pathogenesis of the 1918 Pandemic Influenza Virus
por: Watanabe, Tokiko, et al.
Publicado: (2011)

Recurring and Adaptable Binding Motifs in Broadly Neutralizing Antibodies to Influenza Virus Are Encoded on the D3-9 Segment of the Ig Gene
por: Wu, Nicholas C., et al.
Publicado: (2018)

Influenza H3 hemagglutinin vaccine with scrambled immunodominant epitopes elicits antibodies directed toward immunosubdominant head epitopes
por: Chiba, Shiho, et al.
Publicado: (2023)

Highly Pathogenic H5 Influenza Viruses Isolated between 2016 and 2017 in Vietnamese Live Bird Markets
por: Guan, Lizheng, et al.
Publicado: (2023)

A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage
por: Shinya, Kyoko, et al.
Publicado: (2010)

Characterization of highly pathogenic clade 2.3.4.4b H5N1 mink influenza viruses
por: Maemura, Tadashi, et al.
Publicado: (2023)

Selection of antigenically advanced variants of seasonal influenza viruses
por: Li, Chengjun, et al.
Publicado: (2016)

Protective Immunity and Persistent Lung Sequelae in Domestic Cats after SARS-CoV-2 Infection
por: Chiba, Shiho, et al.
Publicado: (2021)

A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory Viruses
por: Mitchell, Hugh D., et al.
Publicado: (2013)

Cross-Reactive T Cells Are Involved in Rapid Clearance of 2009 Pandemic H1N1 Influenza Virus in Nonhuman Primates
por: Weinfurter, Jason T., et al.
Publicado: (2011)

The COVID-19 Pandemic—A Potential Role for Antivirals in Mitigating Pandemics
por: Neumann, Gabriele, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_gqfan3lmhqgbn5h0bcrp52kb4h