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Fine-Tuning of Mast Cell Activation by FcεRIβ Chain

Mast cells play a key role in allergic reaction and disorders through the high affinity receptor for IgE (Fc(ε)RI) which is primarily activated by IgE and antigen complex. In humans, mast cells express two types of Fc(ε)RI on the cell surface, tetrameric αβγ(2) and trimeric αγ(2), whereas in mice, t...

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Autores principales: Ra, Chisei, Nunomura, Satoshi, Okayama, Yoshimichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353146/
https://www.ncbi.nlm.nih.gov/pubmed/22623922
http://dx.doi.org/10.3389/fimmu.2012.00112
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author Ra, Chisei
Nunomura, Satoshi
Okayama, Yoshimichi
author_facet Ra, Chisei
Nunomura, Satoshi
Okayama, Yoshimichi
author_sort Ra, Chisei
collection PubMed
description Mast cells play a key role in allergic reaction and disorders through the high affinity receptor for IgE (Fc(ε)RI) which is primarily activated by IgE and antigen complex. In humans, mast cells express two types of Fc(ε)RI on the cell surface, tetrameric αβγ(2) and trimeric αγ(2), whereas in mice, the tetrameric αβγ(2) type is exclusively expressed. In human allergic inflammation lesions, mast cells increase in number and preferentially express the αβγ(2) type Fc(ε)RI. By contrast, in the lesion of non-allergic inflammation, mast cells mainly express the αγ(2)type. Since the β chain amplifies the expression and signaling of FcεRI, mast cell effector functions and allergic reaction in vivo are enhanced in the presence of the β chain. In contrast, a truncated β chain-isoform (βT) inhibits FcεRI surface expression. The human Fc(ε)RIβ gene contains seven exons and a repressor element located in the forth intron, through which Fc(ε)RIβ transcription is repressed in the presence of GM-CSF. Regarding the additional signal regulatory function of the β chain, the β chain ITAM has dual (positive and negative) functions in the regulation of the mast cell activation. Namely, the Fc(ε)RIβ chain ITAM enhances the mast cell activation signal triggered by a low-intensity (weak) stimulation whereas it suppresses the signal triggered by high-intensity (strong) stimulation. In an oxazolone-induced mouse CHS model, IgE-mediated mast cell activation is required and the β chain ITAM is crucially involved. Adenosine receptor, one of the GPCRs, triggers a synergistic degranulation response with FcεRI in mast cells, for which the β chain ITAM critically plays positive role, possibly reflecting the in vivo allergic response. These regulatory functions of the FcεRIβ ITAM finely tune FcεRI-induced mast cell activation depending on the stimulation strength, enabling the Fc(ε)RIβ chain to become a potential molecular target for the development of new strategies for therapeutic interventions for allergies.
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spelling pubmed-33531462012-05-23 Fine-Tuning of Mast Cell Activation by FcεRIβ Chain Ra, Chisei Nunomura, Satoshi Okayama, Yoshimichi Front Immunol Immunology Mast cells play a key role in allergic reaction and disorders through the high affinity receptor for IgE (Fc(ε)RI) which is primarily activated by IgE and antigen complex. In humans, mast cells express two types of Fc(ε)RI on the cell surface, tetrameric αβγ(2) and trimeric αγ(2), whereas in mice, the tetrameric αβγ(2) type is exclusively expressed. In human allergic inflammation lesions, mast cells increase in number and preferentially express the αβγ(2) type Fc(ε)RI. By contrast, in the lesion of non-allergic inflammation, mast cells mainly express the αγ(2)type. Since the β chain amplifies the expression and signaling of FcεRI, mast cell effector functions and allergic reaction in vivo are enhanced in the presence of the β chain. In contrast, a truncated β chain-isoform (βT) inhibits FcεRI surface expression. The human Fc(ε)RIβ gene contains seven exons and a repressor element located in the forth intron, through which Fc(ε)RIβ transcription is repressed in the presence of GM-CSF. Regarding the additional signal regulatory function of the β chain, the β chain ITAM has dual (positive and negative) functions in the regulation of the mast cell activation. Namely, the Fc(ε)RIβ chain ITAM enhances the mast cell activation signal triggered by a low-intensity (weak) stimulation whereas it suppresses the signal triggered by high-intensity (strong) stimulation. In an oxazolone-induced mouse CHS model, IgE-mediated mast cell activation is required and the β chain ITAM is crucially involved. Adenosine receptor, one of the GPCRs, triggers a synergistic degranulation response with FcεRI in mast cells, for which the β chain ITAM critically plays positive role, possibly reflecting the in vivo allergic response. These regulatory functions of the FcεRIβ ITAM finely tune FcεRI-induced mast cell activation depending on the stimulation strength, enabling the Fc(ε)RIβ chain to become a potential molecular target for the development of new strategies for therapeutic interventions for allergies. Frontiers Research Foundation 2012-05-16 /pmc/articles/PMC3353146/ /pubmed/22623922 http://dx.doi.org/10.3389/fimmu.2012.00112 Text en Copyright © 2012 Ra, Nunomura and Okayama. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Immunology
Ra, Chisei
Nunomura, Satoshi
Okayama, Yoshimichi
Fine-Tuning of Mast Cell Activation by FcεRIβ Chain
title Fine-Tuning of Mast Cell Activation by FcεRIβ Chain
title_full Fine-Tuning of Mast Cell Activation by FcεRIβ Chain
title_fullStr Fine-Tuning of Mast Cell Activation by FcεRIβ Chain
title_full_unstemmed Fine-Tuning of Mast Cell Activation by FcεRIβ Chain
title_short Fine-Tuning of Mast Cell Activation by FcεRIβ Chain
title_sort fine-tuning of mast cell activation by fcεriβ chain
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353146/
https://www.ncbi.nlm.nih.gov/pubmed/22623922
http://dx.doi.org/10.3389/fimmu.2012.00112
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