Cargando…

The NAMPT inhibitor FK866 reverts the damage in spinal cord injury

BACKGROUND: Emerging data implicate nicotinamide phosphoribosyl transferase (NAMPT) in the pathogenesis of cancer and inflammation. NAMPT inhibitors have proven beneficial in inflammatory animal models of arthritis and endotoxic shock as well as in autoimmune encephalitis. Given the role of inflamma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Esposito, Emanuela, Impellizzeri, Daniela, Mazzon, Emanuela, Fakhfouri, Gohar, Rahimian, Reza, Travelli, Cristina, Tron, Gian Cesare, Genazzani, Armando A, Cuzzocrea, Salvatore
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353188/ https://www.ncbi.nlm.nih.gov/pubmed/22490786 http://dx.doi.org/10.1186/1742-2094-9-66

Ejemplares similares

Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy
por: Galli, Ubaldina, et al.
Publicado: (2020)

A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT
por: Barraud, Marine, et al.
Publicado: (2016)

The NAMPT Inhibitor FK866 Increases Metformin Sensitivity in Pancreatic Cancer Cells
por: Parisotto, Maxime, et al.
Publicado: (2022)

The NAMPT Inhibitor FK866 in Combination with Cisplatin Reduces Cholangiocarcinoma Cells Growth
por: Pant, Kishor, et al.
Publicado: (2023)

Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells
por: Thakur, Basant Kumar, et al.
Publicado: (2013)

Synthesis and Evaluation of Reactive Oxygen Species Sensitive Prodrugs of a NAMPT Inhibitor FK866
por: Xu, Zili, et al.
Publicado: (2022)

Olprinone Attenuates the Acute Inflammatory Response and Apoptosis after Spinal Cord Trauma in Mice
por: Esposito, Emanuela, et al.
Publicado: (2010)

Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
por: Aprile, Silvio, et al.
Publicado: (2019)

Neuroprotective Activities of Palmitoylethanolamide in an Animal Model of Parkinson's Disease
por: Esposito, Emanuela, et al.
Publicado: (2012)

Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α
por: Esposito, Emanuela, et al.
Publicado: (2012)

NAMPT and NAPRT serum levels predict response to anti-TNF therapy in inflammatory bowel disease
por: Colombo, Giorgia, et al.
Publicado: (2023)

PDE 7 Inhibitors: New Potential Drugs for the Therapy of Spinal Cord Injury
por: Paterniti, Irene, et al.
Publicado: (2011)

Cross resistance to diverse anticancer nicotinamide phosphoribosyltransferase inhibitors induced by FK866 treatment
por: Ogino, Yoko, et al.
Publicado: (2018)

FK866 inhibits the epithelial-mesenchymal transition of hepatocarcinoma MHCC97-H cells
por: Zhang, Bin, et al.
Publicado: (2018)

The Cytokine Nicotinamide Phosphoribosyltransferase (eNAMPT; PBEF; Visfatin) Acts as a Natural Antagonist of C-C Chemokine Receptor Type 5 (CCR5)
por: Torretta, Simone, et al.
Publicado: (2020)

IDO Downregulation Induces Sensitivity to Pemetrexed, Gemcitabine, FK866, and Methoxyamine in Human Cancer Cells
por: Maleki Vareki, Saman, et al.
Publicado: (2015)

Editorial: Role of serotonergic system in pathology of major depressive disorders
por: Fakhfouri, Gohar, et al.
Publicado: (2022)

MK801 attenuates secondary injury in a mouse experimental compression model of spinal cord trauma
por: Esposito, Emanuela, et al.
Publicado: (2011)

Neuroprotective effects of FK866 against traumatic brain injury: Involvement of p38/ERK pathway
por: Tan, Zhongju, et al.
Publicado: (2020)

FK866 Protects Human Dental Pulp Cells against Oxidative Stress-Induced Cellular Senescence
por: Ok, Chang Youp, et al.
Publicado: (2021)

A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury
por: Paterniti, Irene, et al.
Publicado: (2013)

Erratum to: A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury
por: Paterniti, Irene, et al.
Publicado: (2016)

The Association of Palmitoylethanolamide with Luteolin Decreases Autophagy in Spinal Cord Injury
por: Siracusa, Rosalba, et al.
Publicado: (2015)

Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma
por: Paterniti, Irene, et al.
Publicado: (2013)

Co-Ultramicronized Palmitoylethanolamide/Luteolin Promotes Neuronal Regeneration after Spinal Cord Injury
por: Crupi, Rosalia, et al.
Publicado: (2016)

Role of TNF-α in lung tight junction alteration in mouse model of acute lung inflammation
por: Mazzon, Emanuela, et al.
Publicado: (2007)

MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866
por: Huang, Peixin, et al.
Publicado: (2017)

FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy
por: Guo, Enshuang, et al.
Publicado: (2017)

Selective adenosine A(2A )receptor agonists and antagonists protect against spinal cord injury through peripheral and central effects
por: Paterniti, Irene, et al.
Publicado: (2011)

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer
por: Travelli, Cristina, et al.
Publicado: (2023)

Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice
por: Elena, Talero, et al.
Publicado: (2012)

A Nicotinamide Phosphoribosyltransferase Inhibitor, FK866, Suppresses the Growth of Anaplastic Meningiomas and Inhibits Immune Checkpoint Expression by Regulating STAT1
por: Deng, Yuxuan, et al.
Publicado: (2022)

PPAR-α Contributes to the Anti-Inflammatory Activity of Verbascoside in a Model of Inflammatory Bowel Disease in Mice
por: Esposito, Emanuela, et al.
Publicado: (2010)

Quantitative Analysis of Daporinad (FK866) and Its In Vitro and In Vivo Metabolite Identification Using Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry
por: Park, Minjae, et al.
Publicado: (2022)

Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies
por: Paterniti, Irene, et al.
Publicado: (2014)

COLLABORATION AGREEMENT K 866
por: THE EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH, CERN, et al.
Publicado: (2002)

Treatment with green tea extract attenuates secondary inflammatory response in an experimental model of spinal cord trauma
por: Paterniti, Irene, et al.
Publicado: (2009)

Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain
por: Impellizzeri, Daniela, et al.
Publicado: (2014)

Anti-Inflammatory and Neuroprotective Effects of Co-UltraPEALut in a Mouse Model of Vascular Dementia
por: Siracusa, Rosalba, et al.
Publicado: (2017)

Erratum to: Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain
por: Impellizzeri, Daniela, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_5ha9k5i171rrdge10gfhevd9u8