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Characterization of the transcriptome profiles related to globin gene switching during in vitro erythroid maturation
BACKGROUND: The fetal and adult globin genes in the human β-globin cluster on chromosome 11 are sequentially expressed to achieve normal hemoglobin switching during human development. The pharmacological induction of fetal γ-globin (HBG) to replace abnormal adult sickle β(S)-globin is a successful s...
Autores principales: | Li, Biaoru, Ding, Lianghao, Li, Wei, Story, Michael D, Pace, Betty S |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353202/ https://www.ncbi.nlm.nih.gov/pubmed/22537182 http://dx.doi.org/10.1186/1471-2164-13-153 |
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