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Thyroid Hormone-Induced Cytosol-to-Nuclear Translocation of Rat Liver Nrf2 Is Dependent on Kupffer Cell Functioning

L-3,3′,5-triiodothyronine (T(3)) administration upregulates nuclear factor-E2-related factor 2 (Nrf2) in rat liver, which is redox-sensitive transcription factor mediating cytoprotection. In this work, we studied the role of Kupffer cell respiratory burst activity, a process related to reactive oxyg...

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Detalles Bibliográficos
Autores principales: Videla, Luis A., Cornejo, Pamela, Romanque, Pamela, Santibáñez, Catherine, Castillo, Iván, Vargas, Romina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353293/
https://www.ncbi.nlm.nih.gov/pubmed/22649286
http://dx.doi.org/10.1100/2012/301494