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Targeting of the Human Coagulation Factor IX Gene at rDNA Locus of Human Embryonic Stem Cells
BACKGROUND: Genetic modification is a prerequisite to realizing the full potential of human embryonic stem cells (hESCs) in human genetic research and regenerative medicine. Unfortunately, the random integration methods that have been the primary techniques used keep creating problems, and the prima...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353886/ https://www.ncbi.nlm.nih.gov/pubmed/22615895 http://dx.doi.org/10.1371/journal.pone.0037071 |