Crystal Structure of a Complex of DNA with One AT-Hook of HMGA1

We present here for the first time the crystal structure of an AT-hook domain. We show the structure of an AT-hook of the ubiquitous nuclear protein HMGA1, combined with the oligonucleotide d(CGAATTAATTCG)(2), which has two potential AATT interacting groups. Interaction with only one of them is foun...

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Detalles Bibliográficos
Autores principales: Fonfría-Subirós, Elsa, Acosta-Reyes, Francisco, Saperas, Núria, Pous, Joan, Subirana, Juan A., Campos, J. Lourdes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353895/
https://www.ncbi.nlm.nih.gov/pubmed/22615915
http://dx.doi.org/10.1371/journal.pone.0037120