Clinical Severity of β-thalassaemia/Hb E Disease Is Associated with Differential Activities of the Calpain-Calpastatin Proteolytic System

Earlier observations in the literature suggest that proteolytic degradation of excess unmatched α-globin chains reduces their accumulation and precipitation in β-thalassaemia erythroid precursor cells and have linked this proteolytic degradation to the activity of calpain protease. The aim of this s...

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Detalles Bibliográficos
Autores principales: Sukati, Suriyan, Svasti, Saovaros, Stifanese, Roberto, Averna, Monica, Panutdaporn, Nantika, Penglong, Tipparat, Melloni, Edon, Fucharoen, Suthat, Katzenmeier, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353910/
https://www.ncbi.nlm.nih.gov/pubmed/22615919
http://dx.doi.org/10.1371/journal.pone.0037133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353910/
https://www.ncbi.nlm.nih.gov/pubmed/22615919
http://dx.doi.org/10.1371/journal.pone.0037133

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