Tetrahydrouridine Inhibits Cell Proliferation through Cell Cycle Regulation Regardless of Cytidine Deaminase Expression Levels

Tetrahydrouridine (THU) is a well characterized and potent inhibitor of cytidine deaminase (CDA). Highly expressed CDA catalyzes and inactivates cytidine analogues, ultimately contributing to increased gemcitabine resistance. Therefore, a combination therapy of THU and gemcitabine is considered to b...

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Detalles Bibliográficos
Autores principales: Funamizu, Naotake, Lacy, Curtis Ray, Fujita, Kaori, Furukawa, Kenei, Misawa, Takeyuki, Yanaga, Katsuhiko, Manome, Yoshinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353937/
https://www.ncbi.nlm.nih.gov/pubmed/22616006
http://dx.doi.org/10.1371/journal.pone.0037424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353937/
https://www.ncbi.nlm.nih.gov/pubmed/22616006
http://dx.doi.org/10.1371/journal.pone.0037424

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