Evolutionary Constraint Helps Unmask a Splicing Regulatory Region in BRCA1 Exon 11

BACKGROUND: Alternative splicing across exon 11 produces several BRCA1 isoforms. Their proportion varies during the cell cycle, between tissues and in cancer suggesting functional importance of BRCA1 splicing regulation around this exon. Although the regulatory elements driving exon 11 splicing have...

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Detalles Bibliográficos
Autores principales: Raponi, Michela, Douglas, Andrew G. L., Tammaro, Claudia, Wilson, David I., Baralle, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353946/
https://www.ncbi.nlm.nih.gov/pubmed/22615956
http://dx.doi.org/10.1371/journal.pone.0037255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353946/
https://www.ncbi.nlm.nih.gov/pubmed/22615956
http://dx.doi.org/10.1371/journal.pone.0037255

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