Interferon-β Induces Cellular Senescence in Cutaneous Human Papilloma Virus-Transformed Human Keratinocytes by Affecting p53 Transactivating Activity

Interferon (IFN)-β inhibits cell proliferation and affects cell cycle in keratinocytes transformed by both mucosal high risk Human Papilloma Virus (HPV) and cutaneous HPV E6 and E7 proteins. In particular, upon longer IFN-β treatments, cutaneous HPV38 expressing cells undergo senescence. IFN-β appea...

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Detalles Bibliográficos
Autores principales: Chiantore, Maria V., Vannucchi, Serena, Accardi, Rosita, Tommasino, Massimo, Percario, Zulema A., Vaccari, Gabriele, Affabris, Elisabetta, Fiorucci, Gianna, Romeo, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353995/
https://www.ncbi.nlm.nih.gov/pubmed/22615843
http://dx.doi.org/10.1371/journal.pone.0036909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353995/
https://www.ncbi.nlm.nih.gov/pubmed/22615843
http://dx.doi.org/10.1371/journal.pone.0036909

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