Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrP(res )level disparity

BACKGROUND: Prion disease transmission and pathogenesis are linked to misfolded, typically protease resistant (PrP(res)) conformers of the normal cellular prion protein (PrP(C)), with the former posited to be the principal constituent of the infectious 'prion'. Unexplained discrepancies ob...

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Detalles Bibliográficos
Autores principales: Lewis, Victoria, Haigh, Cathryn L, Masters, Colin L, Hill, Andrew F, Lawson, Victoria A, Collins, Steven J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355018/
https://www.ncbi.nlm.nih.gov/pubmed/22534096
http://dx.doi.org/10.1186/1750-1326-7-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355018/
https://www.ncbi.nlm.nih.gov/pubmed/22534096
http://dx.doi.org/10.1186/1750-1326-7-18

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