Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases

The ASXL1 gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. ASXL1 mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic...

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Autores principales: Gelsi-Boyer, Véronique, Brecqueville, Mandy, Devillier, Raynier, Murati, Anne, Mozziconacci, Marie-Joelle, Birnbaum, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355025/
https://www.ncbi.nlm.nih.gov/pubmed/22436456
http://dx.doi.org/10.1186/1756-8722-5-12
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author Gelsi-Boyer, Véronique
Brecqueville, Mandy
Devillier, Raynier
Murati, Anne
Mozziconacci, Marie-Joelle
Birnbaum, Daniel
author_facet Gelsi-Boyer, Véronique
Brecqueville, Mandy
Devillier, Raynier
Murati, Anne
Mozziconacci, Marie-Joelle
Birnbaum, Daniel
author_sort Gelsi-Boyer, Véronique
collection PubMed
description The ASXL1 gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. ASXL1 mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). They are generally associated with signs of aggressiveness and poor clinical outcome. Because of this, a systematic determination of ASXL1 mutational status in myeloid malignancies should help in prognosis assessment.
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spelling pubmed-33550252012-05-18 Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases Gelsi-Boyer, Véronique Brecqueville, Mandy Devillier, Raynier Murati, Anne Mozziconacci, Marie-Joelle Birnbaum, Daniel J Hematol Oncol Review The ASXL1 gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. ASXL1 mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). They are generally associated with signs of aggressiveness and poor clinical outcome. Because of this, a systematic determination of ASXL1 mutational status in myeloid malignancies should help in prognosis assessment. BioMed Central 2012-03-21 /pmc/articles/PMC3355025/ /pubmed/22436456 http://dx.doi.org/10.1186/1756-8722-5-12 Text en Copyright ©2012 Gelsi-Boyer et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Gelsi-Boyer, Véronique
Brecqueville, Mandy
Devillier, Raynier
Murati, Anne
Mozziconacci, Marie-Joelle
Birnbaum, Daniel
Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases
title Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases
title_full Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases
title_fullStr Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases
title_full_unstemmed Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases
title_short Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases
title_sort mutations in asxl1 are associated with poor prognosis across the spectrum of malignant myeloid diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355025/
https://www.ncbi.nlm.nih.gov/pubmed/22436456
http://dx.doi.org/10.1186/1756-8722-5-12
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