Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

BACKGROUND: T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into Th1, Th2, Th17 or iTreg phenotypes, depending on environmental co-stimulatory signals. To identify genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes we p...

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Detalles Bibliográficos
Autores principales: Smeets, Ruben L, Fleuren, Wilco WM, He, Xuehui, Vink, Paul M, Wijnands, Frank, Gorecka, Monika, Klop, Henri, Bauerschmidt, Sussane, Garritsen, Anja, Koenen, Hans JPM, Joosten, Irma, Boots, Annemieke MH, Alkema, Wynand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355027/
https://www.ncbi.nlm.nih.gov/pubmed/22413885
http://dx.doi.org/10.1186/1471-2172-13-12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355027/
https://www.ncbi.nlm.nih.gov/pubmed/22413885
http://dx.doi.org/10.1186/1471-2172-13-12

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