Collapse of Telomere Homeostasis in Hematopoietic Cells Caused by Heterozygous Mutations in Telomerase Genes

Telomerase activity is readily detectable in extracts from human hematopoietic stem and progenitor cells, but appears unable to maintain telomere length with proliferation in vitro and with age in vivo. We performed a detailed study of the telomere length by flow FISH analysis in leukocytes from 835...

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Detalles Bibliográficos
Autores principales: Aubert, Geraldine, Baerlocher, Gabriela M., Vulto, Irma, Poon, Steven S., Lansdorp, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355073/
https://www.ncbi.nlm.nih.gov/pubmed/22661914
http://dx.doi.org/10.1371/journal.pgen.1002696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355073/
https://www.ncbi.nlm.nih.gov/pubmed/22661914
http://dx.doi.org/10.1371/journal.pgen.1002696

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